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Coming straight off years of playing Kelly Bundy on "Married... with Children," Christina Applegate worried that Elle Woods would take her back into territory she'd already covered. She passed.

Reese Witherspoon stepped into the pink wardrobe instead, and Applegate has since .

Emily Blunt's Marvel career nearly started years before her eventual brushes with superhero casting rumors. She was lined up to play Natasha Romanoff, but .

Scarlett Johansson took over as Black Widow and stayed with the MCU for more than a decade.

Another romance with Leonardo DiCaprio wasn't enough to lure Claire Danes aboard "Titanic" shortly after the pair made "Romeo + Juliet." Danes has said there was serious interest in her for Rose, .

Kate Winslet ultimately boarded the ship.

Cher Horowitz could have had a very different '90s wardrobe icon wearing those knee-high socks. Sarah Michelle Gellar was offered the part, but .

Alicia Silverstone got the role, while Gellar soon found her own generation-defining character in "Buffy the Vampire Slayer."

A scheduling conflict, not screen-worthiness, took Mel Gibson out of the running here. Ridley Scott wanted him for Maximus, but Gibson was already committed to shooting Roland Emmerich's "The Patriot" at the same time.

"I was doing The Patriot, so I couldn't do Gladiator, so Russell got it, and he did a great job," . Russell Crowe inherited the sword, the sandals, and eventually an Academy Award for Best Actor.

Once wasn't enough: . Director David Frankel recalled that she simply wasn't interested in taking the part, despite the studio's persistence.

Anne Hathaway eventually landed the job opposite Meryl Streep, making Runway's famously unforgiving office part of 2000s movie history.

Jack Nicholson didn't reject Michael Corleone because he thought the movie would fail; . Paramount had considered him while pushing back against Al Pacino's casting, but Nicholson declined.

Pacino's quiet transformation into the Corleone family's new don ultimately became one of his defining performances.

The darkness of "The Silence of the Lambs" was precisely what made Michelle Pfeiffer uncomfortable about playing Clarice Starling. , so she walked away.

Jodie Foster took the case and earned her second Best Actress Oscar.

By the end of the 1980s, Molly Ringwald had already defined a particular corner of romantic comedy, but "Pretty Woman" wasn't the next step she wanted. .

Julia Roberts took the part and emerged from the film as one of Hollywood's biggest leading stars.

Not every missed role comes with lingering regret. , later observing that Meg Ryan and Tom Hanks were an ideal pairing for the movie.

Roberts already had her own era-defining romantic hit with "Pretty Woman," so things worked out rather well on both sides.

Tom Selleck actually wanted to grab Indiana Jones' fedora, and Steven Spielberg and George Lucas wanted him to wear it. .

Harrison Ford was brought in, and one scheduling conflict permanently changed the face of adventure movies.

A talking raccoon and tree did not exactly scream guaranteed blockbuster to Amanda Seyfried. , while the lengthy makeup process and filming commitment also held little appeal.

Zoe Saldaña went green instead, and Seyfried has freely admitted her box-office prediction was wrong.

The Wachowskis' pitch for "The Matrix" didn't click with Will Smith when he was approached about playing Neo. leaving Keanu Reeves to dodge bullets and question reality.

Years later, Smith conceded that Reeves was the right fit and that his own version likely wouldn't have worked nearly as well.

Two enormous 1994 movies could have made John Travolta's comeback look very different. and win his second consecutive Best Actor Oscar.

Travolta hardly spent the year empty-handed, though: "Pulp Fiction" revitalized his own career at virtually the same moment.

Bruce Willis couldn't quite see how a romance was supposed to work when its leading man was already dead. where he could have starred opposite his then-wife Demi Moore.

Patrick Swayze accepted the supernatural love story, and Willis later admitted he'd badly misjudged the concept.

Three years away from home was a bigger commitment than Nicolas Cage wanted to make when Aragorn came his way. he later explained.

The future king of Gondor eventually went to Viggo Mortensen, and Cage has since said he's content experiencing the trilogy as a viewer.

Hannibal Lecter was far too disturbing for Sean Connery's taste. Director Jonathan Demme considered the former James Bond for the brilliant cannibal psychiatrist, but .

Anthony Hopkins had no such reservations and turned limited screen time into an Oscar-winning performance, one he'd revisit twice.

Buzz Lightyear could have sounded a lot more like Billy Crystal. Pixar approached him about voicing the overconfident space ranger, but Crystal didn't think his own voice fit the character's swagger and passed.

, and Crystal immediately recognized his mistake, but by then Tim Allen had the part. When Pixar later called about "Monsters, Inc.," he wasn't about to make the same mistake twice.

A teenage Jodie Foster was considered for Princess Leia, but an existing Disney contract stood in the way. .

Carrie Fisher became Leia instead, creating a screen presence that would remain inseparable from "Star Wars" for generations.

One enormous franchise was plenty for Hugh Jackman in the mid-2000s. When his agent told him there was interest in having him succeed Pierce Brosnan as James Bond, .

Daniel Craig eventually received the license to kill and reinvented 007 for a new era.

Years of sequels were exactly what made Wolverine unappealing to Viggo Mortensen. He worried about committing himself to the same character indefinitely, and .

Hugh Jackman accepted the claws instead, and ended up playing Logan for decades.

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